AbBiBench
A framework using antibody–antigen complexes to evaluate affinity prediction and antibody redesign.
Scientific domain
Protein design
Designing or optimizing protein sequences
蛋白质设计
14 registered benchmarks and tracks
CaM benchmark
A multistate protein sequence-design benchmark spanning CaM conformations and binding modes.
FLIP
A supervised protein sequence-to-fitness benchmark that turns three experimental landscapes into 15 biologically motivated dataset splits for testing generalization in protein engineering.
FLIP AAV
Seven supervised splits over sampled and machine-designed AAV2 VP-1 capsid variants, measuring generalization across mutation depth, fitness, and sampled-versus-designed pools.
FLIP GB1
Five supervised splits over a downsampled, highly epistatic four-site GB1 immunoglobulin-binding landscape, designed to test mutation-depth and low-to-high-fitness generalization.
FLIP Meltome Thermostability
Three supervised sequence-to-melting-temperature splits spanning all species, human proteins, and a single human cell line, with sequence-cluster-aware train/test separation.
LifeSciBench
Expert-authored, artifact-rich free-response tasks that evaluate realistic research judgment across applied life-science workflows.
PapD benchmark
A multistate protein sequence-design benchmark targeting the multispecific PapD binding interface.
ProteinGym
Versioned deep-mutational-scanning and clinical-variant benchmarks for protein fitness prediction and design in zero-shot and supervised regimes.
ProteinGym DMS Indels
ProteinGym track for predicting experimental fitness measurements of insertion and deletion mutants across deep-mutational-scanning assays.
ProteinGym DMS Substitutions
ProteinGym track for predicting experimental fitness measurements of substitution mutants across deep-mutational-scanning assays.
ProteinLMBench
A creator-curated set of 944 protein-science multiple-choice questions with answer explanations, generated from research literature and released for evaluating text LLM protein understanding.
RfaH benchmark
A multistate protein sequence-design benchmark using the fold-switching conformations of RfaH.
TAPE
A five-task benchmark for protein representation learning spanning secondary structure, residue contacts, remote homology, fluorescence, and stability.
Capability coverage
Registry records tagged Protein design, counted by capability.
Accessible data table
| Capability | Records |
|---|---|
| Knowledge | 1 |
| Evidence synthesis | 1 |
| Retrieval | 1 |
| Prediction | 10 |
| Classification | 4 |
| Regression | 8 |
| Design | 8 |
| Generation | 2 |
| Optimization | 8 |
| Data analysis | 1 |
| Experiment planning | 1 |
| Troubleshooting | 1 |
| Scientific reasoning | 2 |
| Scientific communication | 1 |
Scientific Tasks in this domain
Task mappings are evidence-backed and may be partial for mixed suites.
Coverage-gap reading: zero counts indicate a gap in this registry, not proof that no benchmark exists. Propose a primary source through the contribution form.