Biology-Instructions
A multi-omics sequence-instruction suite with 21 formal predictive tasks across DNA, RNA, protein, and multi-molecule inputs; the final paper reports task-specific held-out evaluations rather than a single aggregate score.
Scientific task · Property and function prediction
Protein stability prediction
Predict stability
蛋白质稳定性预测
Definition and search aliases
- Permanent ID
protein-stability-prediction- Aliases
- thermostability prediction, melting temperature prediction
- Deprecated aliases
- None
- Hierarchy
- Leaf task under Protein property and function prediction
Coverage
3 benchmark families cover this task
Biology-Instructions Protein Stability Prediction
Regression of protein stability from an amino-acid sequence, evaluated with Spearman rank correlation.
Biology-Instructions Protein Thermostability Prediction
Regression of protein thermostability from an amino-acid sequence, evaluated with Spearman rank correlation.
FLIP Meltome Thermostability
Three supervised sequence-to-melting-temperature splits spanning all species, human proteins, and a single human cell line, with sequence-cluster-aware train/test separation.
TAPE
A five-task benchmark for protein representation learning spanning secondary structure, residue contacts, remote homology, fluorescence, and stability.
Evidence-backed count claims
Each row keeps its original unit and basis. Rows with different units or overlapping mappings are never added.
| Benchmark | Mapped task | Coverage | Count | Version | Evidence |
|---|---|---|---|---|---|
| Biology-Instructions root: bioinstruction | Protein stability prediction official-track · high | explicitly-in-scope | 2 tracks Formal evaluation tracks (Protein Stability and Protein Thermostability). | emnlp-2025 | bioinstruction-evidence-paper |
| Biology-Instructions Protein Stability Prediction root: bioinstruction | Protein stability prediction official-track · high | explicitly-in-scope | 68977 examples distinct examples across the published train, validation, and test splits | emnlp-2025 | bioinstruction-stability-evidence-paper |
| Biology-Instructions Protein Thermostability Prediction root: bioinstruction | Protein stability prediction official-track · high | explicitly-in-scope | 7031 examples distinct examples across the published train, validation, and test splits | emnlp-2025 | bioinstruction-thermostability-evidence-paper |
| FLIP Meltome Thermostability root: flip | Protein stability prediction official-track · high | explicitly-in-scope | 27951 examples Sequence-temperature examples in the Mixed split universe. | original-2021 | flip-meltome-evidence-paper |
| TAPE root: tape | Protein stability prediction official-taxonomy · high | explicitly-in-scope | 1 tasks Supervised downstream benchmark tasks. | original-2019 | tape-paper-definition-evidence |
Official evaluations connected to these benchmarks
Runs are included only for benchmark records mapped here (and formal child tracks when a mapped suite is the root). A task mapping does not imply that every run isolates this task.