RNA-binding variant-effect prediction

Predict variant effects on RBP binding.

Task definition

Input granularity: variant plus RNA context
Biological target: RBP binding change
Output representation: delta binding score
ML formulation: regression/ranking
Counting notes: NR

Benchmark coverage

1 benchmarks cover this task

B43Numeric results available

RNP-ΔΔG blind mutation benchmark

Blind and independent RNA–protein affinity tests; only RNA-side mutations are in scope. MS2, diverse-complex and PUM2 tests remain separate protocols.

3 benchmark-wide protocols · 3 benchmark-wide rows (not a task subtotal)

Evaluation protocols

3 protocol units

Protocol	Track	Split / subset	Comparability
`P-B43-ALL6`	six-system retrospective aggregate B43-TR01	retrospective independent systems all six tested systems	same_table_comparable NR
`P-B43-PUM2-R2-528`	PUM2 blind round 2 B43-TR01	blind predictions; independent measurement 528 sequences across four scaffolds	same_table_comparable NR
`P-B43-PUM2-R2-385`	PUM2 blind round-2 subset B43-TR01	blind predictions; independent measurement 385 sequences without mutations at position 5	same_table_comparable NR