RNP-ΔΔG blind mutation benchmark

Blind and independent RNA–protein affinity tests; only RNA-side mutations are in scope. MS2, diverse-complex and PUM2 tests remain separate protocols.

Result coverage

3 result rows across 3 protocols

Primary sources: primary_publication_screened
Related works: targeted_gap_search_completed
Authority readiness: verified_for_internal_use
Literature cutoff: 2026-08-06

Track	Numeric coverage	Evidence closure	Blocker
`B43-TR01` RNP-ΔΔG — RNA mutation effect on protein-binding affinity	numeric_results_available 3 results	closed_with_numeric_evidence	NR

Protocol-level results

Choose the evaluation unit before comparing scores.

Each card keeps the four claim types inside one protocol + metric fingerprint.

RNA-binding variant-effect prediction · B43-TR01 · same_source_table

six-system retrospective aggregate

Full results →

all six tested systems · retrospective independent systems · retrospective experimental

RMSErelative binding affinity RMSE · 1 results

Official baseline

No eligible claimNo qualifying result exists in this snapshot.

Original-table best

No eligible claimNo qualifying result exists in this snapshot.

Official board / challenge leader

No eligible claimNo qualifying result exists in this snapshot.

Strict cross-work SOTA

No eligible claimAn original-table best is never substituted for cross-work SOTA.

Fingerprint: PMF-v1-730D80EE090DFF39D6CB16BE

RNA-binding variant-effect prediction · B43-TR01 · same_source_table

PUM2 blind round 2

Full results →

528 sequences across four scaffolds · blind predictions; independent measurement · blind experimental

RMSErelative binding affinity RMSE · 1 results

Official baseline

No eligible claimNo qualifying result exists in this snapshot.

Original-table best

No eligible claimNo qualifying result exists in this snapshot.

Official board / challenge leader

No eligible claimNo qualifying result exists in this snapshot.

Strict cross-work SOTA

No eligible claimAn original-table best is never substituted for cross-work SOTA.

Fingerprint: PMF-v1-49C560715CCA852E847DB218

RNA-binding variant-effect prediction · B43-TR01 · same_source_table

PUM2 blind round-2 subset

Full results →

385 sequences without mutations at position 5 · blind predictions; independent measurement · blind experimental

RMSErelative binding affinity RMSE · 1 results

Official baseline

No eligible claimNo qualifying result exists in this snapshot.

Original-table best

No eligible claimNo qualifying result exists in this snapshot.

Official board / challenge leader

No eligible claimNo qualifying result exists in this snapshot.

Strict cross-work SOTA

No eligible claimAn original-table best is never substituted for cross-work SOTA.

Fingerprint: PMF-v1-5A2BE2F9AE634D081D693F32